Lipolysis and release

BIOCHEMISTRY 3(2+1)
Lesson 23 : Fatty acid Degradation

Lipolysis and release

Initially in the process of degradation, fatty acids are stored in fat cells (adipocytes). The breakdown of this fat is known as lipolysis. The products of lipolysis, free fatty acids, are released into the bloodstream and circulate throughout the body.

Ketones are produced, and are found in large quantities in ketosis (a state in metabolism occurring when the liver converts fat into fatty acids and ketone bodies which can be used by the body for energy).

The following hormones induce lipolysis: epinephrine, norepinephrine, glucagon and adrenocorticotropic hormone. These trigger 7TM receptors (G protein-coupled receptors), which activate adenylate cyclase. This results in increased production of cAMP, which in turn activates protein kinase A, which subsequently activate lipases found in adipose tissue.

Triglycerides undergo lipolysis (hydrolysis by lipases) and are broken down into glycerol and fatty acids. Once released into the blood, the relatively hydrophobic free fatty acids bind to serum albumin for transport to tissues that require energy. The glycerol also enters the bloodstream and is absorbed by the liver or kidney where it is converted to glycerol 3-phosphate by the enzyme glycerol kinase.

While lipolysis is triglyceride hydrolysis, the process by which triglycerides are broken down, esterfication is the process by which triglycerides are formed. Esterfication and lipolysis are essentially reversals of one another

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Last modified: Monday, 23 January 2012, 6:44 AM