Assimilation of Ammonia

Lesson 24 : Amino Acid Metabolism

Assimilation of Ammonia

  1. Assimilation into amino acids occurs through glutamate and glutamine.
  2. ?-amino group of most amino acids comes from ?-amino group of glutamate by transamination.
  3. Glutamine contributes its side-chain nitrogen in other biosynthetic reactions.
  4. Reaction:

    glutamate dehydrogenase

  5. Another reaction that occurs in some animals is the incorporation of ammonia into glutamine via glutamine synthetase:
  6. h

  7. When ammonium ion is limiting, most of glutamate is made by action of both enzymes to produce the following (sum of both reactions):

  8. gh
Last modified: Monday, 30 January 2012, 7:00 AM