Clinical Nutrition

Lesson 18: Cirrhosis and Portal hypertension

Causes

Excessive alcohol consumption

• Deficiency of proteins, carbohydrates and vitamins
• Affects lipid metabolism by
• Fatty acid synthesis
• Fatty acid oxidation
• Stimulation to produce triglycerides
• Release of lipoproteins
• Uptake of circulatory lipids
• Risk of hepatitis B and C
• Malnutrition: Deficiency of Vitamin A, β-carotene, Vitamin E and C
• Iron overload (Heamochromatosis), Wilson's disease (disturbance in Cu metabolism)
• Chronic viral hepatitis B,C,D and G
• Chronic bile duct obstruction
• Aflatoxins

Presence of drugs and toxins like aflatoxin.

• Malnutrition
• Intestinal by pass
• Vascular disorders
• Metabolic disorders

Hemo chromatosis – where in excess of iron is deposited.

Wilsons disease – where in copper is present in free form due to the deficiency of ceruloplasmin.