Fatty globulation: It is the deposition of droplets of fat in the cells. This process is completely reversible, but if the damage is severe or long lasting it may be followed by necrosis or fibrosis.
Necrosis or death of the cells may be slight and only involve part of the lobule, e.g. ishchaemia due to heart failure causes central necrosis around the hepatic vein, or it may be massive and cause widespread destruction of the organs.
Cirrhosis: Fibrosis, the end result of any liver damage which leads to necrosis and also occurs in the absence of obvious necrosis gives rise to the condition cirrhosis.
Other names: hepatic steatosis or steatohepatitis Fatty liver is the condition of fat accumulation in liver cells (hepatocytes), causing,
Cell enlargement (fatty liver or steatosis)
Damage to the cell (steatohepatitis).
The damage is often minor although a small proportion of patients with steatohepatitis develop liver fibrosis and cirrhosis.
Development: The fat present in the healthy cells is not visible as the water insoluble triglycerides linked to phospholipids and other substances form amphipathic molecule that gets dispersed as micelles in the cell water.
The complex physicochemical environment that permits micelle formation is readily disturbed by the alteration of nutrition of cell by formation of droplets of triglycerides
If there are minimal symptoms, there is no evidence or liver dysfunction or failure, and the liver enzymes are only mildly raised, it may be adequate to advise dietary and other changes and observe the patient.