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General pathology of viral infections
Viral induced Cell Injury
There are three types of cell injury:
Cytocidal effect
Non- cytocidal effect
Persistent infection
Chronic infection
Slow viral infection: Viruses with long incubation period resulting in progressive fatal disease . Example-Lenti virus Latent viral infection: Viral genome exists within the host but no viral replication occurs. Under suitable conditions the virus can be reactivated. Example- Herpes virus Cell lysis due to immune response against virus infected cells Both cytocidal and non cytocidal viruses express new antigens on the surface of infected cells that are recognised by the host as foreign and incite an immune response Example - Cytotoxic T lymphocytes and Natural killer cells. It is one of the most important defence mechanism Cytopathic effect : (CPE) Characterised by inclusion bodies
Syncytia formation
Cell transformation
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