Pathogenesis

PATHOGENESIS

  • In black disease and bacillary haemoglobinuria, the spores, normally present in the intestine, may reach the liver and remain dormant in the kupffer cells.
  • Any destruction of liver tissue could be the initiating factor.
  • The tissue damage is usually due to migration of immature liver fluke (Fasciola hepatica), and anaerobic conditions permits germination of spores, growth of vegetative cells and subsequent production of toxin.
  • Alpha toxin produced in the local area of necrosis and in the liver is adsorbed into the circulation and results in systemic effects.
  • In case of bacillary haemoglobinuria the dominant toxin is beta toxin.
  • Big head in rams develop when sub cutaneous tissues traumatized during fights are subsequently invaded by C.novyi type A.
  • The oedema is the result of vascular damage inflicted by the alpha toxin.
Last modified: Monday, 4 June 2012, 4:42 AM