5.1.3 Characteristics of Immunoglobulin
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5.1.3 Characteristics of Immunoglobulin
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|
Property
|
Ig G
|
Ig M
|
Ig A
|
Ig D
|
Ig E
|
|
Heavy chain
|
γ (Gamma)
|
µ (mu)
|
(alpha)
|
δ( delta)
|
ε (epsilon)
|
|
Mean serum concentration (mg/ml)
|
9
|
1.5
|
3.0
|
0.03
|
0.00005
|
|
Valency
|
2
|
5
|
2
|
2
|
2
|
|
Molecular weight of heavy chain (103)
|
51
|
65
|
56
|
70
|
72
|
|
Mol.wt of entire molecule (103)
|
146
|
970
|
160
|
184
|
188
|
|
Placental transfer
|
Yes
|
No
|
No
|
No
|
No
|
|
Half life in blood (days)
|
21
|
10
|
6
|
3
|
2
|
|
Complement activation
|
Through classical pathway
|
Through classical pathway
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Through alternate pathway
|
---
|
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|
Other characteristics
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Most abundant in body fluids; neutralize toxins, opsonizes bacteria
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First to appear after antigen stimulation,. Very effective agglutinator
|
Secretary antibody protects external surfaces
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Present on B –cell surfaces; B – cell recognition of antigen
|
Anaphylactic – mediating antibody.
|
|
% carbohydrate
|
3
|
7-10
|
7
|
12
|
11
|
|
Last modified: Monday, 19 December 2011, 11:19 AM
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