Diagnostic Laboratory Section

CLINICAL SIGNIFICANCE

Blood urea nitrogen

• High protein diet, dry food diet and canned food may lead blood urea concentration up to 10mg/dl and low protein diet result in decrease urea nitrogen.
• Catabolic break down of tissue as a consequence of fever, trauma, infection and toxemia may result in moderate increase in urea concentration.
• Anything which reduce glomerular filteration rate (GFR)  will cause an increase in blood urea nitrogen.
• Alteration in fluid balance influences urea nitrogen.
• Increase BUN may be seen in haemorrhage in gastrointestinal tract.
• Iatrogenically increased, when administration of  drugs that increase protein catabolism or that decrease protein anabolism.
• In cardiovascular disease, dehydration and hypoadrenocorticism pre renal uremia is most common as the renal flow is reduced in such condition.

Creatinine

• The increase level of creatinine indicates functional impairment of kidney.