Glycogen Synthesis

BIOCHEMISTRY 3(2+1)
Lesson 18 : Gluconeogenesis

Glycogen Synthesis

  1. Not reverse of glycogen degradation because different enzymes are used.
  2. About 2/3 of glucose ingested during a meal is converted to glycogen.
  3. First step is the first step of glycolysis:
  4. h

  5. There are three enzyme-catalyzed reactions:
  6. t

    Glucose 1-phosphate ---------------> UDP-glucose (activated form of glucose)

    h

  7. Glycogen synthase cannot initiate glycogen synthesis; requires pre-existing primer of glycogen consisting of 4-8 glucose residues with ? (1,4) linkage.
  8. Protein called glycogenin serves as anchor; also adds 7-8 glucose residues.
  9. Addition of branches by branching enzyme (amylo-(1,4 --> 1,6)-transglycosylase).
  10. Takes terminal 6 glucose residues from non-reducing end and attaches it via ? (1,6) linkage at least 4 glucose units away from nearest branch.
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Last modified: Monday, 30 January 2012, 5:44 AM