Vitamins and minerals RDA, Deficiency and toxicity

BIOCHEMISTRY 3(2+1)
Lesson 30 : The Role of Vitamins & Minerals in Metabolism

Vitamins and minerals RDA, Deficiency and toxicity

RDA

Deficiency/ toxicity


Vitamin A
Retinol

Men: 3000 IU
Women: 2 700 IU

Deficiency: Night blindness; reduced hair growth in children; loss of apetite; dry, rough skin; lowered resistance to infection; dry eyes.
Overdose:
Headaches; blurred vision; fatigue; diarrhea; irregular periods; joint and bone pain; dry, cracked skin; rashes; loss of hair; vomiting, liver damage.


Beta Carotene
(Pro-Vitamin A)
(See Vitamin A)

Precursor of vitamin A.
The antioxidant properties of this nutrient may be a factor in reducing the risk of certain forms of cancer.


Vitamin D
Men: 100 IU
Women: 100 IU

Deficiency: Rickets in children; bone softening in adults; osteoporosis.
Overdose:
Calcium deposits in organs; fragile bones; renal and cardiovascular damage.


Vitamin E
Men: 9-10 mg
Women: 6-7 mg

Deficiency: Rare, seen primarily in premature or low birth weight babies or children who do not absorb fat properly. Causes nerve abnormalities.
Overdose:
Unknown.
The antioxidant properties of this nutrient may be a factor in reducing the risk of certain forms of cancer.

The antioxidant properties of this nutrient may be a factor in reducing the risk of certain forms of cancer.

Vitamin K
None established.
Estimated at 0.03 mcg/kg

Deficiency:
Defective blood coagulation.
Overdose:
Jaundice in infants.


Thiamine
Vitamin B1

Men: 0.8 - 1.3 mg
Women: 0.8 mg

Deficiency:
Anxiety; hysteria; depression; muscle cramps; loss of apetite; in extreme cases beriberi (mostly in alcoholics).
Overdose:

Unknown, although excess of one B vitamin may cause deficiency of others.


Riboflavin
Vitamin B2

Men: 1.3 - 1.6 mg
Women: 1.1 mg

Deficiency: Cracks and sores around the mouth and nose; visual problems.
Overdose:
See Vitamin B1.


Niacin
Vitamin B3

Men: 16-23 mg
Women: 14-16 mg
Niacin is converted to niacinamide in the body.

Deficiency:
In extreme cases, pellagra, a disease characterized by dermatitis, diarrhea and mouth sores.
Overdose:
Hot flashes; ulcers; liver disorders; high blood sugar and uric acid; cardiac arrythmias.


Pantothenic Acid
Vitamin B5

Men: 2.5 mg
Women: 2.5 mg

Deficiency:
Unclear in humans.
Overdose:
See Vitamin B1.


Vitamin B6
Pyridoxine

Men: 1.8 mg
Women: 1.5 mg

Deficiency:
Anemia, irritability, patches of itchy, scaling skin; convulsions.
Overdose:
Nerve damage.


Vitamin B12
Cyanocobalamin

Men: 2 mcg
Women: 2 mcg

Deficiency:
Pernicious anemia; nerve damage. (Note: Deficiency rare except in strict vegetarians, the elderly or people with malabsorption disorders.)
Overdose:
See Vitamin B1.


Biotin
60 mcg

Deficiency:
Seborrhic dermatitis in infants. Rare in adults, but can be induced by consuming large amounts of egg whites - anorexia, nausea, vomiting, dry scaly skin.
Overdose:
See Vitamin B1


Folic Acid (Folacin)
Men: 180-220 mg
Women: 160-190 mg

Deficiency: Impaired cell division; anemia; diarrhea; gastrointestinal upsets.
Overdose:
Convulsions in epileptics. May mask pernicious anemia (see Vitamin B12 deficiency).

Adequate amounts of this nutrient in the first stage of pregnancy may reduce the risks of neural tube birth defects.

Vitamin C
Ascorbic Acid

Men: 40 mg
Women: 30 mg

Deficiency: Muscle weakness, bleeding gums; easy bruising. In extreme cases, scurvy.
Overdose:
Unknown.

The antioxidant properties of this nutrient may be a factor in reducing the risk of certain forms of cancer. May reduce the effects of the common cold.

Calcium
Men: 800 - 1000 mg
Women: 700-800 mg

Deficiency: Rickets in children; osteomalacia (soft bones) and osteoporosis in adults.
Overdose:
Constipation, Kidney Stones, calcium deposits in body tissues. Hinders absorption of iron and other minerals.


Phosphorus
Men: 1000 mg
Women: 850 mg (3-6 g)

Deficiency: (Rare) Weakness; bone pain; Anorexia.
Overdose:
Hinders body's absorption of calcium.


Magnesium
Men: 230 - 250 mg
Women: 200 - 210 mg

Deficiency: Nausea, irritability, muscle weakness; twitching; cramps, cardiac arrhythmias.
Overdose:
Nausea, vomiting, low blood pressure, nervous system disorders.
Warning:
Overdose can be fatal to people with kidney disease.


Potassium
Men: 40-80 mmol
Women: 40-80 mmol (3-6 g)

Deficiency: Nausea, anorexia, muscle weakness, irritability. (Occurs most often in persons with prolonged diarrhea.)
Overdose:

Rare.


Iron
(Elemental)
Men: 8-10 mg
Women: 8-13 mg

Deficiency:
Skin pallor; weakness; fatigue; headaches; shortness of breath (all signs of iron-deficiency anemia)
Overdose:

Toxic buildup in liver and in rare instances the heart.


Zinc
Men: 12 mg
Women: 9 mg

Deficiency:
Slow healing of wounds; loss of taste; retarded growth and delayed sexual development in children.
Overdose:

Nausea, vomiting; diarrhea; abdominal pain; gastric bleeding.


Selenium
0.05-0.2 mg

Deficiency: Unknown in humans.
Overdose:
Finger nail changes, hair loss.


Copper
2-3 mg

Deficiency:
Rare in adults. Infants may develop a type of anemia marked by abnormal development of bones, nerve tissue and lungs.
Overdose:

Liver disease; vomiting; diarrhea.


Manganese
2-5 mg

Deficiency: Unknown in humans.
Overdose:
Generally results from inhalation of manganese containing dust or fumes, not dietary ingestion.


Molybdenum
0.15-0.3 mg

Deficiency: Unknown in humans.
Overdose:
Gout-like joint pain.



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Last modified: Monday, 19 March 2012, 9:42 AM