Fish Immunology (1+1)

Unit 11 - Immunologic tolerance

11.2. General features of Immunologic tolerance
Tolerance is antigenic specific and results from the recognition of antigens by specific lymphocytes.
Normal individuals are tolerant of their own antigens (self antigen) -----Self-tolerance.
Foreign antigens may be administered in ways that can preferentially inhibit immune response by inducing tolerance in specific lymphocytes and it is called antigen induction.
Tolerance can be referred as specific immunological non-reactivity to an antigen resulting from a previous exposure to the same antigen. While the most important form of tolerance is non-reactivity to self antigens, it is possible to induce tolerance to non-self antigens. When an antigen induces tolerance, it is termed tolerogen.