AGB 121: Principles of Animal Genetics and Population Genetics (2+1)

MIS - SENSE MUTATION

• Mutations occurring at the first or second nucleotide position of a codon which results in the replacement of one amino acid in a polypeptide chain by another.
  • For example: one of the codons for phenylalanine is UUU.
  • A second base substitution (U --> G) changes it to UGU, the codon for cysteine
• This may results in a change of the activity of the protein.
• This change may be harmful or beneficial.