Inbreeding
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Inbreeding means the mating together of individuals that are related to each other by ancestry
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Pairs mating at random are more closely related to each other in a small population than in a large one.
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Hence, the properties of small population can be treated as the consequence of inbreeding.
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So the degree of relationship between the individuals in a population depends on the size of the population.
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Genes may be similar or identical due to two different reasons
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Homozygotes – Identical by descent
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Two genes are identical by descent (autozygous) if they are biochemical replicates produced without mutation from a common ancestral gene.
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Homozygotes - Alike in state (independent/ allozygous)
Inbreeding coefficient
Panmictic index is the probability that genes at any single locus are independent by descent P = (1 – F)
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The inbreeding coefficient of subsequent generations expresses the amount of dispersive process that has taken place since the formation of the base population.
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The amount of dispersive process expressed in terms of increment of inbreeding or rate of inbreeding is ΔF = 1/2N
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Therefore, the increment of inbreeding can be used instead of the population size to estimate the variance of change of gene frequency
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Last modified: Saturday, 17 December 2011, 11:23 AM