Synthesis and metabolism of serotonin

SYNTHESIS AND METABOLISM OF SEROTONIN

Tryptophan

Metabolism of serotonin

  • Serotonin is metabolised by two pathways.
  • Mono amine oxidases convert serotonin to 5-hydroxy indoleacetic acid and dehydroxygenases convert serotonin to 5-hydroxy tryptophol.
  • Conversion of 5-hydroxytryptophan to 5- hydroxytryptamine by decarboxylase enzyme is the rate limiting step in the synthesis of serotonin.
Last modified: Tuesday, 15 May 2012, 8:17 AM