VPT 321: Veterinary Neuropharmacology (2+1)

CLINICAL USES OF ANGIOTENSIN

Hypertension

Used as first line of drugs in all grades of hypertension.

Advantages

• No postural hypotension,electrolyte disturbances, weakness, and CNS effects.
• Safe for diabetic, asthamatics, peripheral vascular disease patients.
• Prevent secondary hyperaldosteronism and potassium loss due to diuretics
• Renal flow is maintained
• Reverse left ventricuar hypertrophy
• No adverse effect on lipid profile
• No rebound hypertension on withdrawal
• Increase the life expectancy of hypertensives.

Congestive Heart failure

• Retard the progression of ventricular systolic dysfunction and prolong survival of CHF patients

Myocardial infarction

• Advocated within 24 hours of attack and continued for more weeks - reduce early as well as long term mortality, irrespective of systolic dysfunction and hypotension is avoided.

Diabetic nephropathy

• Prolonged therapy prevents end stage renal disease in both insulin and non insulin dependant situations. It is of value in diabetic nephropathy whether hypertensive or not.