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General
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Shock
Definition
Causes of shock
Classification of shock
Primary shock (Syncope, fainting)
Secondary shock It is fatal Causes of shock
Classification based on fundamental underlying problem
Cardiogenic shock results from failure of heart to adequately pump blood.
Hypovolumic shock arises from reduced circulatory blood volume due to blood loss caused by haemorrhage of fluid loss secondary to vomiting, diarrhoea or burns. This leads to decreased vascular permeability and tissue hypoperfusion.
Blood maldistribution shock is characterised by decrease peripheral vascular resistance and pooling of blood in peripheral tissue. The systemic vascular dilatation results may dramtically increase microvascular area and although the blood volume is normal. The effective circulating blood volume is decreased.
Interaction of an inciting substance with Ig E and mast cell results in mast cell degranulation, release of histamine and systemic vascular dilatation, increased vascular permeability and tissue hypoperfusion.
Here autonomic discharge that results in peripheral dilatation followed by venous pooling of blood and tissue hypoperfusion. When compared to anaphylactic and endotoxic shock wherein cytotoxic plays a major role in intial peripheral vascular dilatation.
Pathogenesis of shock
Septic shock Vasoactive principles Symptoms of shock
Microscopical appearance
Significance and results
Morphology of shock
Macroscopical appearance
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