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Photosensitisational dermatitis
Photosensitisation is activation of photodynamic chemicals on the skin by long wave length UV or occasionally by visible light. Necrosis and edema are produced in the exposed areas of skin of animals. The cellular damage by photosensitization is due to release of reactive oxygen species leading to mast cell degranulation and production of chemical mediators of inflammation. Factors necessary for photosensitization in animals
Types of photosensitization
Type I: Primary Photosensitization
Type II: Abnormal porphyrin metabolism associated photosensitization Due to inherited enzyme deficiency, abnormal porphyrin photodynamic metabolic products like uroporphyrin and protoporphyrin accumulate in blood and tissues. The uroporphyrin also causes discolouration of bone known as “osteohaemochromatosis” and teeth called “pink teeth”.
Type III: Hepatogenous photosensitization
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