General and Systematic Veterinary Pharmacology

DISTRIBUTION OF DRUGS

• Drugs taken throughout the body by bloodstream
• Once absorbed, it gets distributed to other tissues which had no drug

The factors that govern

• Lipid solubility, pH, pKa etc.
• Blood flow to the organ
• Binding and tissue affinity of drugs
• Circulatory disorders, kidney diseases
• Competition among drugs for binding sites

Blood flow rate limiting step in distribution

• Highly perfused organs such as Liver, Kidney, GI tract, Brain, Lungs receive rapidly high levels of drug.
• Lesser levels are achieved in less perfused organs like muscle, fat tissue.