Drug accumulation
-
In first order kinetics, on repeated dose within the complete elimination of the previous dose, drug accumulates in the body.
-
Plateau (steady state) achieved within 4 –5 half lives. The Css is the average of min. and max. of the steady state or the plateau state.
-
For long term therapy, it is aimed to have the therapeutic conc. as Css
-
Target Cp = Css
-
Dose rate = (target Cp x Cl ) (mg / kg per time)/F
-
In some cases immediate higher dose is to be given (otherwise target Cp will be reached only after 4 – 5 half lives)
-
In such cases, Loading dose = (target Cp x Vd )/F
|
Last modified: Wednesday, 25 April 2012, 6:59 AM