Receptor mediated drug action
RECEPTOR MEDIATED DRUG ACTION
|
Most important type of drug action
-
Receptor is a binding site within biological tissues for either endogenous or exogenous(!!!) substances
-
Macromolecules situated on the surface of the cell or inside the cell
-
Regulate critical functions like enzyme activity, permeability, structural features, etc
Evidence
-
Many drugs show structural specificity minor substitution alters the effect.
-
Stereospecificity of drugs d-propranolol less active than l-isomer, l-noradrenaline – more potent than d- noradrenaline
-
antagonism between substances of closely related structures some chemical identity Langley (1878) proposed the term receptive substance
-
This idea developed by Clark (1920) – propounded the Receptor occupation theory D + R DR E (effect)
-
The postulates of the theory are:
|
Last modified: Wednesday, 25 April 2012, 7:03 AM