Factors that affect drug action
FACTORS THAT AFFECT DRUG ACTION
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Factors modifying drug action:
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Body size: influenzes the conc. achieved at the site of action. Doses are normally given for adults of medium build. In extreme cases – dose to be actually calculated based on per kg dose.
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Age: drug behavior differs in infants and children. – low GFR,
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In the old, poor metabolizing capacity, low PP binding, slower Absorption – dose alteration needed in both cases
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Sex: Females smaller in size and may need lower dose.
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Species – changes in sp. in the pattern of metabolism – rabbits resist
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Race – Blacks need higher atropine to dilate pupil Mongols need lower dose
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Diet and plane of nutrition – drug action predictable in good plane of nutrition
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Genetics – G-6-PD deficiency hemolysis with antimalarial agents Malignant hyperthermia after halothane in some human individuals and pigs
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Last modified: Wednesday, 25 April 2012, 7:17 AM