Proton pump antagonists
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Proton pump inhibitors are also called as acid blockers. Examples of this group of drugs are omeprazole, lansoprazole, pantoprazole etc.
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These drugs irreversibly inhibit K+H+-ATPase proton pump in gastrointestinal parietal cells i.e. inhibits entry of H+ ion entry into lumen.
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These drugs also appear to have antimicrobial activity against H. pylori.
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These drugs break down in the acid environment of the stomach and must be given orally as enteric coated preparations and they have short plasma half-lives but are long acting.
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They inhibit hepatic drug metabolism and are very well tolerated.
- These drugs heal duodenal ulcers more rapidly than H2 antagonists.
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They are used primarily for ulcers refractory to other treatments and are also used for reflux esophagitis and management of gastrinomas.
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Last modified: Wednesday, 25 April 2012, 10:02 AM