Actions of calcium-channel blockers
ACTIONS OF CALCIUM-CHANNEL BLOCKERS
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Most clinical ventricular arrhythmias are neither prevented nor suppressed by calcium-channel blockers
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Calcium-channel blockers are useful in treating arrhythmias involving re-entry within the AV node and in the rare forms of monomorphic ventricular tachycardia seen in patients with structurally normal myocardium
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Many of the calcium-channel blockers also have the ability to block sodium channels, probably due to the similarity in their amino acid sequences (sequence homology)
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Calcium-channel blockade is enhanced by verapamil (and to a lesser extent by diltiazem) as the frequency of depolarization is increased
Diltiazem
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For SVTs ,hypertension
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Dose: Dogs 0.125-0.35mg/kg i.v, chronic management- 0.5-1.5mg/kg p.o q8h
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Cats – 0.5-1mg/kg p.o
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Ferrets – ( hypertrophic cardiomyopathy)- 2-7.5mg/kg p.o twice daily
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V erapamil-
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Dose: Dogs – 0.05mg/kg i.v slowly, repeat every 5 minutes oral- 0.5-2mg/kg.q.8h
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Last modified: Wednesday, 25 April 2012, 11:33 AM