Parasympatholytics
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Parasympatholytics such as atropine have been used as a bronchodilator in chronic emphysema in horses.
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The rationale is that atropine overcomes the muscarinic cholinoceptor-mediated bronchoconstriction. The effect is dilation of the larger airways
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Atropine derivatives e.g. eucatropine, have also long been used in paediatric preparations for whooping cough.
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As the sulphate, atropine is routinely injected preoperatively to reduce or eliminate salivary and bronchial secretions during anesthesia.
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The dose by subcutaneous injection is 30-100 m g / kg.
- Ipratropium a muscarinic – blocking bronchodilator, is used as an aerosol.
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The reduction in volume, higher viscosity of secretions and decreased mucociliary clearance, can be a disadvantage.
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Last modified: Wednesday, 25 April 2012, 12:04 PM