Mast cell stabilizer
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The drug acts by stabilizing mast-cell membranes preventing degranulation and the release of chemical mediators (eg. Histamine and leukotrienes) in response to allergens.
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A depressant action on chemosensitive ending which trigger bronchoconstriction is also suggested.
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More recently it has been shown also to prevent the release of tissue-damaging free radicals of IgE activated platelets.
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Cromoglycate is not a bronchodilator and is not effective in the rapid relief of existing bronchoconstriction.
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It has given sufficient improvement in the respiratory function in horses with chronic obstructive pulmonary disease.
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Adminsitration is done via a special nebulizer and face – mask, 80 mg once daily for 1-4 days. The 10-15 min period of nebulization is generally well accepted by the horse.
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It is available as drug for protecting horses with allergic respiratory disease against predictable antigen challenge.
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Last modified: Wednesday, 25 April 2012, 12:06 PM