Classification of diuretics
Based on their action on the kidneys diuretics are classified as
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Diuretics acting directly on the cells of the nephron
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Agents acting on the ascending loop of Henle – Ethacrynic acid, frusemide
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Agents acting on the early distal tubules – Thiazides like chlorthiazide
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Agents acting on the Collecting tubules and ducts – Triamterene, amiloride
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Diuretics modifying the contents of the filtrate
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Based on their mode of action diuretics are classified as
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Inhibitors of carbonic anhydrase – Acetazolamide, dichlorphenamidine
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Inhibitors of Na+-K+-2Cl- symport (High ceiling loop diuretics) – Frusemide, Ethacrynic acid, Bumetanide
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Inhibitors of Na+-Cl- symport – Thiazide and thiazide like drugs
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Potassium sparing diuretics
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Inhibitors of epithelial sodium channels – Triamterene, amiloride
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Antagonists of aldosterone – Spironolactone
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Xanthine diuretics – Theophylline
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It can also be classified as
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Cardiac diuretics - Xanthines
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Natriuretics - Mercurials, Thiazides, Acetazolamide
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Last modified: Wednesday, 25 April 2012, 12:09 PM