Veterinary Clinical Biochemistry and Laboratory Diagnosis

CLINICAL SIGNIFICANCE

• The increased level of creatinine indicates functional impairment of kidney. The rate of creatinine excretion is influenced by GFR and any other abnormality that decrease GFR result in an increase in concentration of creatinine.
• In the earlier stages, Creatinine clearance test is a sensitive index of impaired renal function.
• The prerenal factors that increase blood urea have less influences on creatinine concentration. Hence for diagnosis of renal diseases, serum creatinine is preferred over urea estimation.
• In addition to renal disease, elevated level of serum creatinine and creatinuria may be observed in extensive muscle destruction.