Special Veterinary Pathology

Azoturia/ Paralytic myoglobinuria / Monday morning sickness

AZOTURIA

Synonym:  Paralytic myoglobinuria / Monday morning sickness

• Occurs in working horses following a few days of rest while on full rations.
• Clinical signs include trembling, profuse sweating, recumbency
• Serum activities of creatinine kinase, alkaline phosphatase and aspartate amino transferase are increased.
• Grossly, muscles have foci of discolorations and haemorrhages

- Kidney Swollen and congested.

- Urinary bladder contains brown urine (myoglobinuria)

• Microscopically, Myofiber degeneration and necrosis is characterised by swollen, eosinophilic, hyaline, fragmented myofibers with loss of striations, macrophages infiltrate areas of necrosis.
• Renal tubular necrosis with myoglobin casts are seen.