Veterinary Taxicology

TOXICOKINETICS

• Aflatoxins are rapidly absorbed from the gastrointestinal tract.
• They are bound to serum albumin.
• Liver removes most of the toxins from the blood stream.
• In hepatocytes it binds to macromolecules like DNA, endoplasmic sterol binding sites and enzymes.
• Metabolites formed may be water-soluble conjugates or lipid soluble forms. Some metabolites undergo enterohepatic recirculation.
• They are excreted in milk, faeces and urine.
• Complete elimination takes several days.