Veterinary Neuropharmacology

TRUE AND PSEUDO ACETYLCHOLINESTERASES

	True Cholinesterase	Pseudo Cholinesterase
Distribution	All cholinergic nerve sites, RBC, gray matter	Plasma, liver, intestine, white matter
Acetylcholine	Hydrolysed very fast	Hydrolysed slow
Methacholine	Hydrolysed slower than Ach	Not hydrolysed
Benzoylcholine	Not hydrolysed	Hydrolysed
Butyrylcholine	Not hydrolysed	Hydrolysed
Inhibition	More sensitive to physostigmine	More sensitive to organophosphates
Function	Termination of acetylcholine action	Hydrolysis of ingested esters