Systematic Veterinary Virology

RESISTANCE

• Under in vitro conditions virions relatively stable. The FMD virus is pH sensitive and is inactivated at pH below 6.5 or above 11. In milk and milk products, the virion can survive at 70^ºC for 15 seconds and pH 4.6. The virus in cell culture medium will remain viable for a year at 4^ºC.
• The virus in serum or other organic material will survive drying and can be carried on inanimate objects. In meat, the virus can survive for long periods in chilled or frozen bone marrow and lymph nodes.
• The virus inactivated by sodium hydroxide (2%), sodium carbonate (4%), and citric acid (0.2%) and is Resistant to iodophores, quaternary ammonium compounds, hypoclorite and phenol, especially in the presence of organic matter.