Systematic Veterinary Virology

REPLICATION

• The glycoprotein spikes are responsible for attaching to receptors on the cell. The entire replication of the virus takes place in the cytoplasm.
• The (+) sense genomic RNA acts directly as mRNA. The entire genome is translated as a single polyprotein, which is then cleaved into the mature proteins.
• The NS protein synthesizes complementary (-)strand, which used as a template for genomic progeny RNA synthesis.
• Assembly occurs during budding into cytoplasmic vacuoles than at the cell surface and release of progeny virion occurs when cell lyses.