Systematic Veterinary Virology

REPLICATION

• Replication of BVDV begins with receptor-mediated endocytosis into a cell.
• The E₂ glycoprotein mediates this step. Once inside the cell, the viral RNA is released and RNA translation begins immediately.
• Viral proteins can be obseved as early as three hours after cell infection. Following gene translation, the large polyprotein product is processed by both cellular and viral enzymes into mature proteins.
• One of the protein is the RNA-dependent RNA polymerase. New genomic RNA is produced to be packaged into virus packages.
• Viral packaging occurs in either the Golgi apparatus or endoplasmic reticulum where they acquire their lipid envelope through budding into the vesicle lumen.
• Mature virus packages are then released from the cell exocytosis. New virus can be released as early as 10 hours post cell infection.