Systematic Veterinary Virology

CONTROL - VACCINATION

• Since the serotypes are immunologically distinct monovalent, quadrivalent and polyvalent vaccines are used to control AHSV. The problem with modified live attenuated vaccines are that they do not allow differentiation between vaccinated and infected animals and may aid in persistence of the virus
  • A live attenuated vaccine was developed by adapting  the virus to the brains of adult mice. This vaccine though offers protection, occasionally caused encephalitis in horses mules and particularly in donkeys.
  • An alternate and safe vaccine was developed by attenuation of the virus in Vero cell cultures. This vaccine is currently used in South Africa, which consists of two quadrivalent vaccines that are administered 3 weeks apart.