Systematic Veterinary Virology

REPLICATION

• Virus replication occurs in the cytoplasm and does not affect the cells own synthesis of RNA and proteins (There is no complet shut off). The two double stranded DNA-segments, A and B, code for different viral proteins (VP).
• The replication is characterized by presence of subgenomic RNAs - a mRNA, a transcription of RNA-A and RNA-B.
• The non-structural protein VP5 has been shown to be important since it causes lysis of the host cells and release of the virus.
• The protein accumulates in the plasma membrane and causes cell deformation prior to cell lysis.