Systematic Veterinary Virology

REPLICATION

• Adenoviruses replicate in the nucleus. Replication is divided into early and late phases. Entry of adenovirus particle is a two-stage process involving an initial interaction of the fibre protein with cellular receptors followed by interaction between cell proteins and pentamers, which results in the entry of virus into the cell.
• Virus entry also involves phagocytosis of virus particles into phagocytic vacuoles. Due to the toxic activity of the pentons phagocytic membrane ruptures and release the virus into the cytoplasm. The viral core migrates to the nucleus where the DNA enters through nuclear pores. The genome replicates in the nucleus and occurs by a strand-displacement mechanism.
• Virions may provide helper functions to dependent virus during replication. They also act as helper for a satellite virus. Progeny virions assemble in the nucleus and are released from host cell by disintegration