Systematic Veterinary Virology

TRANSMISSION

• Dogs recovered from ICH shed the virus in their urine for upto six months. The infection is transmitted from affected animal to normal animals through ingestion of urine, faeces, or saliva from affected animal. Initial infection occurs in the tonsillar crypts and Peyer's patches, followed by viremia and infection of endothelial cells in many tissues. Liver, kidneys, spleen, and lungs are the main target organs for multiplication of virus.