Field diagnosis: Clinical signs are difficult to differentiate from canine distemper. Sudden onset with severe bleeding is suggestive of ICH. The symptoms should be correlated with blood picture before arriving at final diagnosis.
Histopathology of liver and demonstration of specific intranuclear inclusion bodies
Isolation and identification: Cell culture systems developed from kidney cells of dogs or ferrets are used for isolation. The presence of virus is confirmed by
Demonstration of intranuclear inclusion bodies
Immunofluoorescense
Polymerase chain reaction
Differential diagnosis: Canine distemper and CAV 2 infection (infectious tracheobronchitis)