Systematic Veterinary Virology

PATHOGENESIS

• The incubation period is long under field conditions. All CAV isolates cause anemia and/or aplastic bone marrow. Eight days after infection the haematocrit levels, thrombocytes and red and white cell counts decrease. Blood takes longer to clot
• Between 28 – 36 days post infection the heamathological parameters in recovered birds return to normal. Under experimental conditions the virus is found present in most organs after one day  in brain, liver, spleen, bursa, bone marrow, rectal contents and serum. CAV can be found latent in SPF flocks where the virus was detected in the ovaries, oviduct, testicles and spleen of birds without obvious seroconversion until the birds came into production.