Chemistry

CHEMISTRY

  • Parathyroid hormone (PTH) is a single chain polypeptide containing 84 amino acids.
  • PTH is synthesized as part of a large molecule containing 115 amino acids called pre pro-parathyroid hormone (pre‑pro PTH) by the ribosome.
  • This large molecule is converted to pro-PTH composed of 90 amino acids in the rough endoplasmic reticulum. It moves to the Golgi apparatus and is enzymatically cleaved to produce the biologically active PTH.
  • Active PTH may be secreted directly or packaged into secretory granules.
Last modified: Friday, 6 January 2012, 9:13 AM