Veterinary Physiology-III

ATRIAL NATRIURETIC PEPTIDE

• The Atrial Natriuretic Peptide (ANP) is synthesised and stored in the atrial muscles as 126 amino acid proANP which is cleaved to become 28-amino acid active hormone.
• Secretion of ANP is stimulated by increase in atrial pressure caused either by pressor agents or by increase in atrial volume.
• On kidney, ANP produces natriuretic and diuretic effects, increases GFR, renal excretion of water, Na, Ca, Cl, Mg and phosphate.
• The ANP blocks the secretion of vasopressin from neurohypophysis and angiotensin II or ACTH stimulated release of aldosterone from adrenal cortex.
• ANP causes decrease in blood pressure. It inhibits renin secretion.