Veterinary Immunology and Serology

BONE MARROW

• Bone marrow is probably the largest secondary lymphoid tissue in the body.
• If antigens are given intravenously, some antigen will be trapped in the bone marrow.
• During the primary immune response, antibodies are largely produced in the spleen and Lymphnode.
• Towards the end of that response, the memory cells leave the spleen and colonize in bone marrow.
• When a second dose of antigen is given, the bone marrow produces very large quantities of antibodies and is the major sources of IgG in adult rodents.