Veterinary Immunology and Serology

DESTRUCTION OF INGESTED MICROBES

• Ingested particles are destroyed by the different mechanisms 
  • Oxygen dependent pathway:
    • By release of reactive oxygen intermediates (ROIs), called as respiratory burst
    • By release of reactive nitrogen intermediates e.g. nitric oxide
  • Oxygen independent pathway:
    • By lysomomal enzymes or other hydrolytic enzymes, defensins and other cationic proteins.