Veterinary Clinical Medicine-I (General and Systemic)

NEONATAL ISOERYTHROLYSIS

• Maternal antibodies produced against RBC antigens of newborn or fetus.
• Newborn inherits antigen from sire that is not present on dam’s RBC.
• Maternal antibodies form as a result of exposure to fetal RBCs in previous pregnancy (or blood tranfusion).
• Most common in horse and human.
• In Horses, neonate born healthy; but show signs of hemolytic anemia with in hours, days of birth after ingestion of colostrum.