Veterinary Clinical Medicine-I (General and Systemic)

ANTIBIOTICS AND DOSES RECOMMENDED IN SEPTIC PATIENTS 

Drug	Dosage	Route	Freq	Gram Spectrum
Ampicillin	20-40 mg/kg	IV	TID	G+, G-, some anaerobes
Penicillin G,	20,000-	IV, IV,	TID	G+, G-, anaerobes
aqueous	100,000 U/kg	SC
Cefazolin1	20 mg/kg	IV	TID	G+, some G-, some anaerobes
Cephalothin1	20-30 mg/kg	IV	QID	G+, some G-, some anaerobes
Cefotaxime3	20-80 mg/kg	IV, IM	TID	G+, some G-, some anaerobes
Cefoxitin2	20 mg/kg	IV	TID	some G+, some G-, some anaerobes
Trimethoprimsulfa	15 mg/kg	IV, IM	BID	some G+, G-, some anaerobes
Enrofloxacin	5-10 mg/kg 5-20 mg/kg	IV IV	SID	some G+, G-
Ciprofloxacin	5-15 mg/kg 10-20 mg/kg	PO PO	SID	some G+, G-,
Amikacin	10-15 mg/kg	IV	SID	few G+, good G-,
Gentamicin	6-9 mg/kg	IV, IM, SC	SID BID	few G+, good G-,
Tobramycin	2-4 mg/kg	IV	TID	few G+, good G-,
Clindamycin	10-12 mg/kg	IV	BID	some G+, few G-, anaerobes
Metronidazole	10 mg/kg	IV as CRI	TID	Anaerobes, protozoa

• Note: ¹first, ²second, ³third generation