VPB 121: Veterinary Physiology - II (2+1)

PHYSICAL PROPERTIES OF BILE

• Bile from hepatic duct is a viscid, greenish or greenish yellow with golden tinge liquid with a bitter taste. 
• The compositions varies upon whether the bile is obtained from gall bladder or from the ducts of the liver. 
• The constituents of the bile are
  • Bile pigments
  • Bile acids or salts of bile acids
  • Cholesterol
  • Lecithine
  • Mucin and alike substances
  • Fat, soap, urea
  • Inorganic substances like Na, K, Ca, Cl and HCO₃

Composition of bile

	Hepatic bile	Gall bladder bile
Water	97.5 gm%	92   gm %
Bile salts	1.1 gm%	6    gm %
Bilirubin	0.04 gm%	0.3 gm %
Cholesterol	0.1 gm%	0.3  - 0.9 gm %
Fatty acids	0.12 gm%	0.3 – 1.2 gm %
Lecithin	0.04 gm%	0.3 gm %
Na+	145 mEq /1	130 mEq/1
K+	5 mEq/1	12 mEq/1
Ca+	5 mEq /1	23 mEq/1
CI	100 mEq/1	25 mEq/1
HCO3	28  mEq/1	10 mEq/1
pH	7.1-7.3	6.9 – 7.7

 Amount of bile secreted  in different species

Horse	250-300 ml/hour
Ox	98-111 ml/hour
Sheep	7-154 ml/hour
Pig	70-140 ml/hour
Dog	7-14 ml /hour
Man (Adult)	300-1200 ml/hour

•  The volume of bile secretion depends on many factors
  • Blood flow to the liver,
  • Digestive state of the animal
  • Composition of food.

Methods of  bile collection

• Bile can be obtained by gall bladder fistula from gall bladder.
• Direct connection of the common bile duct also helps in getting the bile from animals.