General Barriers in innate immunity

GENERAL BARRIERS OF INNATE IMMUNITY

  • General barrier is the non-susceptibility of an individual against a particular disease.
  • Examples: Genetic factors, physiologic factors, nutritional factors etc.
  • Genetic factors
    • Species specificity - Rinderpest is a disease of animals (cattle, sheep and goats) but not for human beings. FMD virus does not infect horses and dogs.
    • Genetically resistant groups - For example, African blacks are more susceptible to tuberculosis in America. White coloured (B1 line) broiler chickens are more susceptible to Hydro pericardium syndrome disease etc.
  • Physiologic factors 
    • Cold blooded animals are not susceptible to tetanus toxins.
    • Body temperature at 42 o c (birds) does not allow many organisms to grow even Fever is beneficial to the body.
    • Age: Very young and old age groups are susceptible to infection with many organisms.
Last modified: Wednesday, 25 August 2010, 11:41 AM