VMC 221: Veterinary Immunology and Serology (1+1)

STABILITY

• Antigen molecule must be stable and rigid. For example gelatin, a protein known for its instability is a poor antigen but they become stable when amino acid residue like tyrosine or tryptophan are incorporated which cross link the peptide chain.
• Similarly flagellin is a weak antigen and its stability and antigenicity are enhanced by polymerization.