VPT 311: General and Systemic Veterinary Pharmacology (2+1)

PROTON PUMP ANTAGONISTS

• Proton pump inhibitors are also called as acid blockers. Examples of this group of drugs are omeprazole, lansoprazole, pantoprazole etc.
• These drugs irreversibly inhibit K+H+-ATPase proton pump in gastrointestinal parietal cells i.e. inhibits entry of H+ ion entry into lumen.
• These drugs also appear to have antimicrobial activity against H. pylori.
• These drugs break down in the acid environment of the stomach and must be given orally as enteric coated preparations and they have short plasma half-lives but are long acting.
• They inhibit hepatic drug metabolism and are very well tolerated.
• These drugs heal duodenal ulcers more rapidly than H₂ antagonists.
• They are used primarily for ulcers refractory to other treatments and are also used for reflux esophagitis and management of gastrinomas.