VPT 311: General and Systemic Veterinary Pharmacology (2+1)

ECBOLICS 

• These are agents that bring about increase in uterine contractions.
• Oxytocin: It is hormone of the posterior pituitary received from the hypothalamus. It has amajor physiological role in milk let down and labor initiation.
• Clinical uses of oxytocin:
• For labor induction. Given by slow I/v in dextrose solution.
• For mIlk letdown . Only in agalactic animals
• For treatment of uterine inertia and for rapd involution of uterus.
• To arrest postparturient haemorrhage.
• For expulsion of retained placenta.
• The dose of oxytocin is 5 - 25 units in bitch, 75 - 100 units in cow / mare and 30 - 50 units in sow / ewe.
• Oxytocics: Other agents which perform similar functions are also called oxytocics.
• Ergot alkaloids: Alkaloids from the fungus Claviveps purpurea viz. ergometrine, ergonovine have prominent effect on the uterus. Not preferred for induction of labour. Generally indicated for postparturient haemorrhage, rapid involution of uterus, retained placenta.
• PGF 2 alpha: Exerts potent stimulant action on myometrium. It is also popularly used for its luteolytic effect.